UPSC Combined Medical Services Solved Papers

Patients suffering from which of the following condition(s) can get symptomatic relief by consuming a gluten-free diet?

1. Coeliac disease
2. Peptic ulcer disease
3. Dermatitis herpetiformis

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The '¹³C-urea breath test' and the 'faecal antigen test' are non-invasive techniques to diagnose infection with which one of the following?

Consider the following statements regarding Ménétrier's disease:

1. There is excessive production of Transforming Growth Factor-alpha (TGF-α).
2. Majority of the patients present with features of protein-losing enteropathy.
3. Mucus secreting cells are replaced by parietal and chief cells.
4. The mucosal folds of the body and fundus of the stomach are greatly enlarged.

Which of the statements given above are correct?

Consider the following statements regarding Barrett's 'Oesophagus':

1. It is a pre-malignant condition.
2. The normal columnar mucosa of lower oesophagus is replaced by squamous cells.
3. It is an adaptive response to chronic gastro-oesophageal reflux.

Which of the statements given above is/are correct?

The presence of which of the following is suggestive of metastatic spread of an underlying gastrointestinal malignancy?

1. Krukenberg Tumour
2. Virchow's Node
3. Meigs' Syndrome
4. Sister Mary Joseph's Nodule

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Sodium zirconium cyclosilicate and patiromer are commonly prescribed to chronic kidney disease patients because of their property of binding to which one of the following electrolytes?

Calcium resonium, which is used to treat hyperkalaemia over a short-term in chronic kidney disease, is associated with the development of which one of the following conditions?

In multiple myeloma, monoclonal immunoglobulin light chains combine with Tamm Horsfall protein precipitate in the renal tubules which leads to the development of which one of the following conditions?

Multiple myeloma can cause proximal tubular injury due to light chain deposition in the tubular epithelium causing acquired Fanconi Syndrome. Which of the following are characteristic findings in this condition?

1. Little/no proteinuria
2. Aminoaciduria
3. Phosphaturia
4. Glycosuria

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Which one of the following hereditary tubulo-interstitial kidney diseases shows Autosomal Recessive pattern of inheritance?

Which one of the following is a contraindication of Renal Biopsy?

Anti-PLA2R antibodies, which are directed against the 'M-type phospholipase A2 receptor', are a key biomarker for which one of the following conditions?

Which one of the following stages of chronic kidney disease corresponds to a glomerular filtration rate of 55 mL/min/1.73 m²?

Which one of the following hereditary neuropathies is characterized by elevated serum 'phytanic acid' levels and manifests with the tetrad of peripheral neuropathy, retinitis pigmentosa, cerebellar ataxia and elevated protein concentration in cerebrospinal fluid?

Which one of the following is true regarding asymmetrical motor diabetic neuropathy?

Which of the following are the clinical features of multiple sclerosis?

1. Loss or blurring of vision
2. Tingling in limbs on neck flexion
3. Generalized tonic-clonic seizures
4. Gait ataxia

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A 42-year-old labourer developed a sudden, severe and persistent headache, accompanied by vomiting and neck pain. He was evaluated at the nearest hospital where an emergency computed tomography was negative for stroke. Which one of the following investigations is best to confirm the diagnosis?

Consider the following pairs with respect to muscle channelopathies:

A 47-year-old man with a large frontoparietal lesion in the right hemisphere was asked to circle all the A's. Only targets on the right were circled. This is a manifestation of:

A 40-year-old man was found to have weakness of the right shoulder and arm 6 hours before presentation. This was followed by weakness of the ipsilateral leg, then left leg, followed by left arm (around-the-clock pattern). Where in the neuraxis is the lesion likely to be present?

Which one of the following refers to agraphesthesia?

Which one of the following is a type of Mitochondrial myopathy?

Which one of the following is a childhood onset epilepsy syndrome characterized by multiple seizure types, developmental delay and slow (<3 Hz) spike-and-wave discharges on an electroencephalogram?

With regard to the treatment of phaeochromocytoma, beta-blocker should never be given before alpha-blocker because it may cause:

Which of the following may be seen during clinical examination in a patient of Diabetes mellitus?

1. Necrobiosis lipoidica
2. Charcot neuroarthropathy
3. Exudative maculopathy
4. Acanthosis nigricans

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