Prepare for the UPSC CMS Examination with official questions and detailed clinical solutions across General Medicine, Paediatrics, Surgery, Gynaecology & Obstetrics, and Preventive & Social Medicine.
Marking pattern: +2.00 positive, -0.66 negative (Official UPSC CMS Scheme).
Consider the following statements regarding glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP):
1. GLP-1 is an incretin hormone.
2. GIP is an incretin hormone.
3. GLP-1 is released from gastrointestinal 'L-cells'.
4. GIP is released from gastrointestinal 'M-cells'.
Which of the statements given above are correct?
Consider the following statements regarding 'Factitious Thyrotoxicosis':
1. Induced when patients consume excessive amounts of levothyroxine.
2. The exogenous levothyroxine suppresses pituitary secretion of TSH (thyroid-stimulating hormone).
3. Serum thyroglobulin level is elevated.
4. Tβ: Tβ ratio is high.
Which of the statements given above are correct?
Deficiency of which of the following mineral(s) can lead to hypocalcemia by impairing the ability of the parathyroid gland to secrete parathyroid hormone?
1. Phosphate
2. Magnesium
3. Sodium
4. Potassium
Select the correct answer using the code given below:
Which of the following are long-acting insulin analogues?
1. Lispro
2. Glargine
3. Detemir
4. Degludec
Select the correct answer using the code given below:
Which one of the following levels of hypoglycaemia corresponds to a blood glucose level of < 54 mg/dL (< 3.0 mmol/L) leading to cognitive impairment and need for corrective treatment?
Liquorice misuse, by inhibiting 11 beta-hydroxysteroid dehydrogenase type 2 enzyme, can cause a condition which resembles the clinical features of:
Which of the following is/are growth hormone receptor antagonist(s) indicated in the treatment of Acromegaly?
1. Octreotide
2. Lanreotide
3. Pasireotide
4. Pegvisomant
Select the correct answer using the code given below:
Which of the following statements regarding Autoimmune Polyendocrine Syndromes (APS) is/are correct?
1. APS Type 1 is more common than APS Type 2.
2. APS Type 1 is inherited as an autosomal recessive condition.
3. APS Type 2 is inherited as an autosomal dominant condition.
Select the correct answer using the code given below:
Which one of the following drugs is not a secondary cause of weight gain?
Which one of the following is true for Teriparatide for treatment of osteoporosis?
Post-transplant lymphoproliferative disorder, a lymphoma that follows organ transplantation, is associated with infection with which one of the following?
'Exanthem Subitum' is caused due to infection of which of the following viruses?
1. Human herpesvirus 6
2. Hepatitis-B virus
3. Human herpesvirus 7
4. Hepatitis-C virus
Select the correct answer using the code given below:
'Slapped-cheek' rash is caused by infection with which one of the following viruses?
The neuropsychiatric manifestations of the infectious delirium caused by which one of the following agents presents as 'Muttering Delirium' or 'Coma Vigil' in which patients pick randomly at bed clothes or imaginary objects?
Necrotizing fasciitis caused by fungi such as mucoraceous moulds is classified as which one of the following types?
Infusion of which one of the following antibacterial agents may cause the 'Red Man Syndrome' characterized by rapid onset of erythematous rash and pruritus on the face, neck and upper trunk?
Which one of the following can be classically elicited in a patient of Staphylococcal scalded skin syndrome?
A 35-year-old female presents with generalized muscle rigidity, difficulty swallowing and laryngeal spasms for the past one week. She has developed trismus over the past 2 days and has a pulse rate of 130 beats/minute and a respiratory rate of 35 breaths/minute on presentation. She gives a history of getting her ears pierced from a roadside jewellery seller 2 weeks ago. What is the most probable diagnosis?
A 25-year-old male presents with complaints of urethral discharge and dysuria for the past 1 week. The discharge was scant and mucoid for a few days but he reports profuse and yellowish discharge since 2 days. Gram staining of the urethral discharge reveals gram-negative intracellular monococci and diplococci. On further questioning, he gives history of unprotected sexual intercourse 15 days ago. Which one of the following conditions will be your most probable diagnosis?
A 40-year-old male, upon returning from a beach holiday, noticed a serpiginous, intensely pruritic linear lesion over the dorsum of foot which moved slowly across the skin to reach up to his toes in 5-6 days. The most likely clinical diagnosis is:
Consider the following statements regarding gas gangrene:
1. It is caused by clostridial species, e.g., Clostridium perfringens.
2. It is characterized by a foul-smelling, painful wound containing serosanguineous discharge and gas bubbles.
3. It requires an aerobic environment and affects sites which are richly supplied with blood.
4. Radical amputation carries a high risk of advancing the infection to healthy tissue and is strictly contraindicated.
Which of the statements given above are correct?
Which of the following correctly denote(s) the clinical manifestations of diphtheria?
1. Dermatosis characterized by punched-out ulcerative lesions with necrotic sloughing
2. Dysphonia, dysphagia and headache
3. Myocarditis, cardiac arrhythmias and congestive heart failure
4. Massive tonsillar, submandibular and paratracheal oedema presenting as 'bull-neck' appearance
Select the correct answer using the code given below:
Which one of the following is the vector for Leishmania donovani, the causative organism of Visceral Leishmaniasis?
Casal's Necklace is a characteristic erythema seen in deficiency of which one of the following vitamins?
Wickham's striae are typically seen in which one of the following diseases?