UPSC Combined Medical Services Solved Papers

Consider the following statements regarding Molluscum contagiosum:

1. It is caused by Papilloma virus skin infection.
2. It occurs frequently in immunosuppressed patients.
3. Lesions are dome-shaped, umbilicated, skin-coloured papules with central punctum.
4. Gently squeezing the lesions with forceps after bathing can hasten resolution.

Which of the statements given above are correct?

Which one of the following refers to the appearance of punctate bleeding spots on scraping the surface of a skin lesion?

Consider the following statements regarding Complex Regional Pain Syndrome (CRPS):

1. Type 1 CRPS may be precipitated by a traumatic event such as a fracture.
2. Type 1 CRPS is associated with peripheral nerve damage.
3. Type 2 CRPS is associated with peripheral nerve damage.
4. Budapest criteria are used for diagnosis of CRPS.

Which of the statements given above are correct?

Consider the following statements regarding Dual X-ray Absorptiometry (DXA):

1. DXA is used to measure bone mineral density.
2. It works on the principle that calcium in bone attenuates passage of X-rays through the tissue in proportion to the amount of mineral present.
3. Osteoporosis is defined to be present when the T-score lies between (-1.0) and below (+2.5).
4. Co-existing conditions, e.g., aortic calcification or degenerative disc disease can cause high bone mineral density even in the presence of osteoporosis.

Which of the statements given above are correct?

Which of the following classical disease-modifying anti-rheumatic drugs is/are considered safe for use during pregnancy?

1. Methotrexate
2. Sulfasalazine
3. Hydroxychloroquine
4. Leflunomide

Select the correct answer using the code given below:

Finkelstein's sign/test is done to diagnose which one of the following conditions?

Which of the following are 'first-rank' symptoms of acute schizophrenia?

1. Auditory hallucinations
2. Broadcasting of thoughts
3. Memory loss
4. Delusional perceptions

Select the correct answer using the code given below:

A 44-year-old woman has fear of contamination leading to her repeated hand-washing. With regard to her management, consider the following statements:

1. Diagnosis is made on the basis of history.
2. The disorder responds to antidepressant drugs.
3. Patients may be subjected to cognitive behaviour therapy.
4. Admission to a psychiatry ward is mandatory.

Which of the statements given above is/are correct?

Consider the following statements with regard to point mutations:

1. If a purine is replaced by another purine, it is called 'transition'.
2. If a purine is replaced by a pyrimidine, it is called 'transversion'.
3. If a pyrimidine is replaced by another pyrimidine, it is called 'transversion'.

Which of the statements given above are correct?

Which one of the following correctly denotes a flat, coloured lesion, < 2 cm in diameter, not raised above the surface of the surrounding skin?

Which one of the following terms correctly denotes the mechanism and phenotypic changes that are not a result of variation in the underlying DNA sequence, but are caused by secondary modifications of DNA or histones in response to other heritable or environmental influences?

'Latrodectism', characterized by local pain and sweating, is caused by the bite of which one of the following animals?

A farmer was suspected of some unknown substance poisoning, as he presented with bronchorrhoea, sweating and excessive salivation. Examination revealed bradycardia with bilateral miosis. Consider the following statements regarding his poisoning:

1. The symptoms represent Anti Cholinergic Syndrome.
2. Activation of Acetylcholinesterase (AChE) enzyme is the underlying mechanism.
3. Intravenous Atropine should be given for treatment.

Which of the statements given above is/are correct?

Which of the following pairs of parasites and associated clinical manifestations are correct?

1. Ancylostoma duodenale : Anemia
2. Ascaris lumbricoides : Löffler Syndrome
3. Loa loa : Katayama Fever
4. Trichinella spiralis : Myositis

Select the answer using the code given below:

Which of the following features are present in Locked-in syndrome?

1. Cerebral cortex is intact.
2. Bilateral motor tracts are damaged.
3. Some response to verbal stimuli may be present.
4. Limb movement occurs in response to noxious stimuli.

Select the correct answer using the code given below:

A 26-year-old female complains of severe fatigue and myalgia. Examination reveals pallor and mild splenomegaly. Haematological investigations are shown below:

Haemoglobin : 10 g/dL
Peripheral smear : Microcytic hypochromic picture with anisocytosis
Reticulocyte count : 5%
Serum ferritin : 300 microgram/L

What is the most likely underlying diagnosis?

Which of the following infectious agents are associated with the development of lymphoid malignancies?

1. HIV
2. Hepatitis B
3. Hepatitis C

Select the correct answer using the code given below:

Which of the following statements regarding Blood component transfusion related acute lung injury are correct?

1. Transfusion related acute lung injury (TRALI) usually manifests within 6 hours of transfusion.
2. Risk factors for TRALI include high titre anti-HLA class II antibodies in donor plasma.
3. TRALI due to cytokines or chemokines can occur even in the absence of HLA mediated interactions.

Select the answer using the code given below:

Match List I with List II and select the correct answer using the code given below the lists:

A 3-year-old boy is brought with barking cough and noisy breathing of 2 days' duration. He has a history of running nose and some fever for the preceding 3-4 days. Examination reveals respiratory rate of 40 per min, subcostal retractions and stridor. The most important step in the management is:

A 3-year-old boy presents to the emergency room with seizures. He has been receiving oral phenytoin since the age of 6 months and has a history of epileptic spasms despite therapy. Examination reveals some hypopigmented lesions over the chest. MRI brain shows subependymal nodules. Which one of the following is the best anti-epileptic drug for him after stabilization in the emergency room?

A 10-year-old girl presents to the emergency with high grade fever of 2-weeks duration and rashes over lower limbs for the last 7 days. Examination reveals mild pallor, generalized petechiae and hepatosplenomegaly. Investigations reveal: Hemoglobin 9 g/dL, total leucocyte count 2100/mm³, platelet count 20,000/mm³, peripheral smear shows pancytopenia, SGOT 50 IU/dL, SGPT 64 IU/dL, serum ferritin 1200 μg/L, serum fibrinogen 100 mg/dL and serum triglycerides of 350 mg/dL. The most likely diagnosis is:

A 5-year-old boy, started on induction chemotherapy for acute lymphoblastic leukemia, develops acute abdominal pain on day 14 of chemotherapy. On abdominal examination, there is marked abdominal tenderness and Cullen's sign is positive. The most likely chemotherapeutic drug which can be implicated is:

A 5-year-old boy who was started on treatment for Burkitt lymphoma develops acute onset respiratory distress and decreased urine output. Investigations reveal: Hb 8 g/dL, TLC 15000/mm³, platelet count 1 lakh/mm³, serum potassium 6.5 mEq/L, corrected serum calcium 6.7 mg/dL and serum creatinine 2 mg/dL. The most important drug for emergency management is:

Consider the following statements regarding human milk banking:

1. The banks accept voluntary milk donations from lactating women who are given nominal payments governed by law.
2. Donor mothers are screened via blood tests for HIV, and Hepatitis B and C, similar to blood donation.
3. Pasteurized donor milk reduces the chances of NEC in preterm neonates.
4. Pasteurized donor milk is non-inferior to fresh mother's own milk (MOM).

Which of the statements given above are correct?